AIM：To study the potentiation of anti-tumor effect induced by cytosine arabinoside (AraC)with(-)-epigallocatechin-3-gallate(EGCG).METHODS:Growth curve method and MTT assay were used to measure the cytotoxic effect of AraC alone or in combination with EGCG on HL-60 cells,Folw cytometry was used to study the cell cycle distribution of HL-60 cells.Nullification assay was used to examine whether EGCG would nullify the rescue effect of dexoycytidine (dCdR)to AraC,Western blot analysis was empolyed to investigate bcl-2 expression .Inracellular Ca^2+ assay was evaluated.RESULTS:Inhibition of HL-60 cell proliferation induced by AraC was enhanced by EGCG,with multiplication time prolonging from 48h to 70h and growth saturation density decreasing from 5.78 to 5.54 .The MTT results indicated that IC50 was decreased from(0.34±0．29）μmol/L（AraC alone)to(0.11±0.09）μmol/L（P
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